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Article

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

Bioorganic & medicinal chemistry - 1 Mar 2013

Novikov Mikhail S, Valuev-Elliston Vladimir T, Babkov Denis A, Paramonova Maria P, Ivanov Alexander V, Gavryushov Sergey A, Khandazhinskaya Anastasia L, Kochetkov Sergey N, Pannecouque Christophe, Andrei Graciela, Snoeck Robert, Balzarini Jan, Seley-Radtke Katherine L

Abstract excerpt

A series of phenyloxyethyl and cinnamyl derivatives of substituted uracils were synthesized and found to exhibit potent activity against HIV-RT and HIV replication in cell culture. In general, the cinnamyl derivatives proved superior to the phenyloxyethyl derivatives, however 1-[2-(4-methylphenoxy)ethyl]-3-(3,5-dimethylbenzyl)uracil (19) exhibited the highest activity (EC(50)=0.27 μM) thus confirming that the...

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Identifiers

PMID: 23357038
DOI: 10.1016/j.bmc.2012.12.027
PMCID: PMC7125863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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