Article
Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.
Bioorganic & medicinal chemistry letters - 15 Oct 2010
Tang Guozhi, Kertesz Denis J, Yang Minmin, Lin Xianfeng, Wang Zhanguo, Li Wentao, Qiu Zongxing, Chen Junli, Mei Jianghua, Chen Li, Mirzadegan Taraneh, Harris Seth F, Villaseñor Armando G, Fretland Jennifer, Fitch William L, Hang Julie Qi, Heilek Gabrielle, Klumpp Klaus
Abstract excerpt
Further investigation of the recently reported piperidine-4-yl-aminopyrimidine class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out. Thus, preparation of a series of N-phenyl piperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Analogs such as 28 and 40 are very potent versus wild-type HIV-1 and a broad range of NNRTI-resistant...
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