Article
Array-based DNA methylation analysis in individuals with developmental delay/intellectual disability and normal molecular karyotype.
European journal of medical genetics - 1 Aug 2015
Kolarova Julia, Tangen Imke, Bens Susanne, Gillessen-Kaesbach Gabriele, Gutwein Jana, Kautza Monika, Rydzanicz Malgorzata, Stephani Ulrich, Siebert Reiner, Ammerpohl Ole, Caliebe Almuth
Abstract excerpt
Despite recent progress in molecular karyotyping and clinical sequencing the cause of intellectual disability in a considerable subset of individuals affected by this phenotype remains elusive. As intellectual disability is also a feature of various imprinting disorders and some monogenic forms of intellectual disability are caused by epigenetic modifiers we hypothesized that changes in DNA methylation might be...
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