Article
Stable prevalence of genotypic drug resistance mutations but increase in non-B virus among patients with primary HIV-1 infection in France.
AIDS (London, England) - 5 Dec 2003
Chaix Marie-Laure, Descamps Diane, Harzic Martine, Schneider Véronique, Deveau Christiane, Tamalet Catherine, Pellegrin Isabelle, Izopet Jacques, Ruffault Annick, Masquelier Bernard, Meyer Laurence, Rouzioux Christine, Brun-Vezinet Françoise, Costagliola Dominique
Abstract excerpt
OBJECTIVE: To evaluate the frequency of drug-resistant HIV-1 viral strains from patients presenting with primary infection in 1999-2000 and to survey the molecular epidemiology of these viruses circulating in France. METHODS: Resistance mutations were detected by sequencing the reverse transcriptase and the protease genes in plasma samples from 249 individuals. Phylogenetic analysis was performed on the reverse...
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