Article
DNA copy number variations characterize benign and malignant thyroid tumors.
The Journal of clinical endocrinology and metabolism - 1 Mar 2013
Liu Yan, Cope Leslie, Sun Wenyue, Wang Yongchun, Prasad Nijaguna, Sangenario Lauren, Talbot Kristen, Somervell Helina, Westra William, Bishop Justin, Califano Joseph, Zeiger Martha, Umbricht Christopher
Abstract excerpt
CONTEXT: Fine-needle aspiration (FNA) is the best diagnostic tool for preoperative evaluation of thyroid nodules but is often inconclusive as a guide for surgical management. OBJECTIVE: Our hypothesis was that thyroid tumor subtypes may show characteristic DNA copy number variation (CNV) patterns, which may further improve the preoperative classification. DESIGN: Our study cohorts included benign follicular...
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