Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology.

doi:10.1089/thy.2015.0305

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Article

Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2015

Nikiforov Yuri E, Carty Sally E, Chiosea Simon I, Coyne Christopher, Duvvuri Umamaheswar, Ferris Robert L, Gooding William E, LeBeau Shane O, Ohori N Paul, Seethala Raja R, Tublin Mitchell E, Yip Linwah, Nikiforova Marina N

Abstract excerpt

BACKGROUND: Fine-needle aspiration (FNA) cytology is a common approach to evaluate thyroid nodules. It offers definitive diagnosis of a benign or malignant nodule in the majority of cases. However, 10-25% of nodules yield one of three indeterminate cytologic diagnoses, leading to suboptimal management of these patients. Atypia of undetermined significance/follicular lesion of undermined significance (AUS/FLUS) is...

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PMID: 26356635
DOI: 10.1089/thy.2015.0305
PMCID: PMC4652198

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HRAS
NRAS

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