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Article

Molecular Profiling of 50 734 Bethesda III-VI Thyroid Nodules by ThyroSeq v3: Implications for Personalized Management.

The Journal of clinical endocrinology and metabolism - 18 Oct 2023

Chiosea Simion, Hodak Steven P, Yip Linwah, Abraham Devaprabu, Baldwin Chelsey, Baloch Zubair, Gulec Seza A, Hannoush Zeina C, Haugen Bryan R, Joseph Lija, Kargi Atil Y, Khanafshar Elham, Livhits Masha J, McIver Bryan, Patel Kepal, Patel Snehal G, Randolph Gregory W, Shaha Ashok R, Sharma Jyotirmay, Stathatos Nikolaos, van Zante Annemieke, Carty Sally E, Nikiforov Yuri E, Nikiforova Marina N

Abstract excerpt

CONTEXT: Comprehensive genomic analysis of thyroid nodules for multiple classes of molecular alterations detected in a large series of fine needle aspiration (FNA) samples has not been reported. OBJECTIVE: To determine the prevalence of clinically relevant molecular alterations in Bethesda categories III-VI (BCIII-VI) thyroid nodules. METHODS: This retrospective analysis of FNA samples, tested by ThyroSeq v3...

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Mutation
Proto-Oncogene Proteins B-raf
Thyroid Neoplasms
Thyroid Nodule

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PMID: 37071871
DOI: 10.1210/clinem/dgad220
PMCID: PMC10583990

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