Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.

The Journal of veterinary medical science - 1 Jan 2013

Fujiwara-Igarashi Aki, Goto-Koshino Yuko, Mochizuki Hiroyuki, Maeda Shingo, Fujino Yasuhito, Ohno Koichi, Tsujimoto Hajime

Abstract excerpt

The p16, p15 and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well analyzed on the aberrations of these genes. In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5' and 3' rapid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor Proteins
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dog Diseases

Share to Gene Expression Regulation, Neoplastic

Share to Lymphocytes

Share to Lymphoma

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 23343657
DOI: 10.1292/jvms.12-0351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.PMID 23343657Read ↗

Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood.Semantic proximity Read ↗

Expression and Significance of p53, Rb, p21/waf-1, p16/ink-4a, and PTEN Tumor Suppressors in Canine MelanomaSemantic proximity Read ↗

Role of the Cyclin-Dependent Kinase 4 and 6 Inhibitor Gene Family p15, p16, p18 and p19 in Leukemia and LymphomaSemantic proximity Read ↗

Molecular analysis of cyclin-dependent kinase inhibitors in human leukemias.Semantic proximity Read ↗

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic featuresSemantic proximity Read ↗

miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumorsSemantic proximity Read ↗

Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesisSemantic proximity Read ↗

Comparative genomic hybridization in detection of DNA changes in canine lymphomas.Semantic proximity Read ↗

[Homozygous deletion of p16 and p15 genes in laryngeal squamous cell carcinoma].Semantic proximity Read ↗

Deletions and rearrangements of cyclin-dependent kinase 4 inhibitor gene p16 are associated with poor prognosis in B cell non-Hodgkin's lymphomas.Semantic proximity Read ↗

Alteration of p16 and p15 genes in human uterine tumours.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.