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Article

Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.

PloS one - 1 Jan 2013

De Araujo Mariana E, Erhart Gertraud, Buck Katharina, Müller-Holzner Elisabeth, Hubalek Michael, Fiegl Heidelinde, Campa Daniele, Canzian Federico, Eilber Ursula, Chang-Claude Jenny, Coassin Stefan, Haun Margot, Kedenko Lyudmyla, Paulweber Bernhard, Reitsamer Roland, Himmel Irmgard, Flesch-Janys Dieter, Lamina Claudia, Kronenberg Florian, Huber Lukas A, Kloss-Brandstätter Anita

Abstract excerpt

BACKGROUND: The late endosomal LAMTOR complex serves as a convergence point for both the RAF/MEK/ERK and the PI3K/AKT/mTOR pathways. Interestingly, both of these signalling cascades play a significant role in the aetiology of breast cancer. Our aim was to address the possible role of genetic poly...

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Source

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Identifiers

PMID: 23341997
DOI: 10.1371/journal.pone.0053768
PMCID: PMC3547070

Genes

LAMTOR2
LAMTOR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23341997-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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