Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.

doi:10.1371/journal.pone.0053768

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Article

Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk.

PloS one - 1 Jan 2013

De Araujo Mariana E, Erhart Gertraud, Buck Katharina, Müller-Holzner Elisabeth, Hubalek Michael, Fiegl Heidelinde, Campa Daniele, Canzian Federico, Eilber Ursula, Chang-Claude Jenny, Coassin Stefan, Haun Margot, Kedenko Lyudmyla, Paulweber Bernhard, Reitsamer Roland, Himmel Irmgard, Flesch-Janys Dieter, Lamina Claudia, Kronenberg Florian, Huber Lukas A, Kloss-Brandstätter Anita

Abstract excerpt

BACKGROUND: The late endosomal LAMTOR complex serves as a convergence point for both the RAF/MEK/ERK and the PI3K/AKT/mTOR pathways. Interestingly, both of these signalling cascades play a significant role in the aetiology of breast cancer. Our aim was to address the possible role of genetic polymorphisms in LAMTOR2 and LAMTOR3 as genetic risk factors for breast cancer. METHODOLOGY/RESULTS: We sequenced the exons...

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PMID: 23341997
DOI: 10.1371/journal.pone.0053768
PMCID: PMC3547070

Genes

LAMTOR2
LAMTOR3

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