Article
Mutations and off-pathway aggregation of proteins.
Trends in biotechnology - 1 May 1994
Wetzel R
Abstract excerpt
The off-pathway aggregation of proteins is a ubiquitous, yet poorly understood, phenomenon. In vitro, aggregation places limits on both protein stability and refolding yields. In vivo, it is responsible for inclusion-body formation in the bacterial production of proteins, as well as amyloid disease and related phenomena in animals. An important common feature of these processes is their sensitivity to point...
Topics
- Amino Acid Sequence
- Animals
- Humans
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Folding
- Proteins