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G‐Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1

21 Jan 2013

Abstract excerpt

Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G-protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over-expressed in ES among sarcoma, but also up-regulated in a number of carcinomas derived from prostate, kidney or lung. Inhibition of GPR64 expression in ES by RNA interference impaired colony formation in vitro...

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PMID: 23338946
DOI: 10.1002/path.4170

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