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Article

CD99 polymorphisms significantly influence the probability to develop Ewing sarcoma in earlier age and patient disease progression.

Oncotarget - 22 Nov 2016

Martinelli Marcella, Parra Alessandro, Scapoli Luca, De Sanctis Paola, Chiadini Valentina, Hattinger Claudia, Picci Piero, Zucchini Cinzia, Scotlandi Katia

Abstract excerpt

Ewing sarcoma (EWS), the second most common primary bone tumor in pediatric age, is known for its paucity of recurrent somatic abnormalities. Apart from the chimeric oncoprotein that derives from the fusion of EWS and FLI genes, recent genome-wide association studies have identified susceptibility variants near the EGR2 gene that regulate DNA binding of EWS-FLI. However, to induce transformation, EWS-FLI requires...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 27792997
DOI: 10.18632/oncotarget.12862
PMCID: PMC5363635

Genes

EGR2

Provenance

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