Article
Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases.
International journal of cancer - 15 Jul 2013
Bermejo Justo Lorenzo, Kabisch Maria, Dünnebier Thomas, Schnaidt Sven, Melchior Frauke, Fischer Hans-Peter, Harth Volker, Rabstein Sylvia, Pesch Beate, Brüning Thomas, Justenhoven Christina, Brauch Hiltrud, Baisch Christian, Ko Yon-Dschun, Hamann Ute
Abstract excerpt
Small ubiquitin-like modifier (SUMO) proteins are covalently attached to target proteins to modify their function. SUMO conjugation participates in processes tightly linked to tumorigenesis. Recently USPL1 (ubiquitin-specific peptidase-like (1) was identified as a SUMO isopeptidase. We report here on the first exploratory study investigating the relationship between genetic variability in USPL1 and breast cancer....
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