Article
A mutation in beta-tubulin and a sustained dependence on androgen receptor signalling in a newly established docetaxel-resistant prostate cancer cell line.
Cell biology international - 25 Jan 2010
Hara Takahito, Ushio Kazutaka, Nishiwaki Mayumi, Kouno Jin, Araki Hideo, Hikichi Yukiko, Hattori Masahiko, Imai Yumi, Yamaoka Masuo
Abstract excerpt
The mechanisms of docetaxel resistance in PC (prostate cancer) are unclear because of the lack of suitable experimental models, and no effective treatment exists for docetaxel-resistant PC. We established a docetaxel-resistant cell line, LNDCr, from an androgen-refractory PC cell line, LNCaP-hr, by intermittent exposure to docetaxel in vitro. The LNDCr cells harboured an F270I mutation in class I beta-tubulin,...
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