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Article

Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea.

PloS one - 1 Jan 2013

Huang Lin, Wang Zhen-Bo, Jiang Zong-Zhe, Hu Meng-Wen, Lin Fei, Zhang Qing-Hua, Luo Yi-Bo, Hou Yi, Zhao Yong, Fan Heng-Yu, Schatten Heide, Sun Qing-Yuan

Abstract excerpt

Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor negatively regulating mammalian target of rapamycin complex 1 (mTORC1). It is reported that mice lacking Tsc1 gene in oocytes show depletion of primordial follicles, resulting in premature ovarian failure and subsequent infertility. A recent study indicated that deletion of Tsc1 in somatic cells of the reproductive tract caused infertility of female mice....

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Identifiers

PMID: 23335988
DOI: 10.1371/journal.pone.0054052
PMCID: PMC3545997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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