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Inhibition of mTOR Signaling Pathway Delays Follicle Formation in Mice

15 Jun 2016

Abstract excerpt

In mammalian ovaries, follicle assembly requires proper germ cell cyst breakdown and the invasion of somatic cells to encapsulate individual oocytes. Abnormalities in this process lead to a number of pathologies such as premature ovarian failure and infertility. As a conserved pathway regulating cell growth and metabolism in response to growth factors and nutrients, the roles of mTOR signaling in follicular...

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PMID: 27301841
DOI: 10.1002/jcp.25456

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