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Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

12 Jan 2021

Abstract excerpt

Sperm-zona pellucida (ZP) interaction, involving the binding of sperm surface ligands to complementary carbohydrates of ZP, is the first direct gamete contact event crucial for subsequent gamete fusion and successful fertilization in mammals. It is a complex process mediated by the coordinated engagement of multiple ZP receptors forming high-molecular-weight (HMW) protein complexes at the acrosomal region of the...

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PMID: 33445482
DOI: 10.3390/cells10010133

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