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Article

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.

Autophagy - 1 Feb 2010

Tresse Emilie, Salomons Florian A, Vesa Jouni, Bott Laura C, Kimonis Virginia, Yao Tso-Pang, Dantuma Nico P, Taylor J Paul

Abstract excerpt

VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ubiquitin-dependent protein degradation by the proteasome. Mutations in VCP cause a multisystem degenerative disease consisting of inclusion body myopathy, Paget disease of bone, and frontotemporal...

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Source

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Identifiers

PMID: 20104022
DOI: 10.4161/auto.6.2.11014
PMCID: PMC2929010

Genes

VCP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.PMID 20104022Read ↗

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.Semantic proximity Read ↗

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.Semantic proximity Read ↗

Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.Semantic proximity Read ↗

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.Semantic proximity Read ↗

Recent advances in p97/VCP/Cdc48 cellular functions.Semantic proximity Read ↗

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.Semantic proximity Read ↗

Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts.Semantic proximity Read ↗

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.Semantic proximity Read ↗

mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathySemantic proximity Read ↗

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and boneSemantic proximity Read ↗

VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration.Semantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

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