Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells.

doi:10.1016/0165-1218(90)90110-n

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Article

Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells.

Mutation research - 1 May 1990

Hartwig A, Schlepegrell R, Beyersmann D

Abstract excerpt

The data concerning the mutagenic, clastogenic and carcinogenic properties of inorganic lead compounds have been conflicting. To investigate whether the genotoxicity of lead is due to indirect effects such as interference with DNA-repair processes, the induction of mutations, sister-chromatid exc...

Topics

Animals
Cells, Cultured
Colony-Forming Units Assay
Cricetinae
DNA Damage
DNA Repair
Dose-Response Relationship, Drug
HeLa Cells
Humans
In Vitro Techniques
Lead
Mutation
Sister Chromatid Exchange
Ultraviolet Rays

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