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Article

Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.

Journal of molecular biology - 6 Feb 2009

Shin David S, Didonato Michael, Barondeau David P, Hura Greg L, Hitomi Chiharu, Berglund J Andrew, Getzoff Elizabeth D, Cary S Craig, Tainer John A

Abstract excerpt

Prokaryotic thermophiles supply stable human protein homologs for structural biology; yet, eukaryotic thermophiles would provide more similar macromolecules plus those missing in microbes. Alvinella pompejana is a deep-sea hydrothermal-vent worm that has been found in temperatures averaging as high as 68 degrees C, with spikes up to 84 degrees C. Here, we used Cu,Zn superoxide dismutase (SOD) to test if this...

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Identifiers

PMID: 19063897
DOI: 10.1016/j.jmb.2008.11.031
PMCID: PMC2669833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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