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Article

Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.

Journal of neuropathology and experimental neurology - 1 Mar 2014

Seo Yoojin, Shin Yooyoung, Kim Hyung-Sik, Kang Insung, Hong In-Sun, Choi Soon Won, Yu Kyung-Rok, Kang Kyung-Sun

Abstract excerpt

Neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (AChE) inhibitors (AChEIs) may have therapeutic potential in some neurological conditions. We evaluated the effects of administration of donepezil, a widely used AChEI, in the cerebellum in a murine model of Niemann-Pick disease type C (NPC). The NPC mice developed Purkinje cell loss at the age...

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PMID: 24487798
DOI: 10.1097/NEN.0000000000000045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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