Polymerase chain reaction for detection of the alpha-1-antitrypsin Z allele in chronic liver disease.

doi:10.1016/0168-8278(90)90059-z

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Article

Polymerase chain reaction for detection of the alpha-1-antitrypsin Z allele in chronic liver disease.

Journal of hepatology - 1 Mar 1990

Brind A M, McIntosh I, Brock D J, James O F, Bassendine M F

Abstract excerpt

The genetic locus for alpha-1-antitrypsin (alpha-AT) is highly polymorphic, but all protein variants are encoded by a single locus on chromosome 14. Periportal hepatocyte granules are described in association with chronic liver disease and the Z variant. A Z-specific point mutation in exon V of t...

Topics

Alleles
Base Sequence
Chronic Disease
Exons
Genotype
Humans
Immunoblotting
Isoelectric Focusing
Liver Diseases
Molecular Sequence Data
Phenotype
Polymerase Chain Reaction
alpha 1-Antitrypsin

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