Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo.

Mutagenesis - 1 Mar 2013

Schults Marten A, Chiu Roland K, Nagle Peter W, Wilms Lonneke C, Kleinjans Jos C, van Schooten Frederik J, Godschalk Roger W

Abstract excerpt

Genetic polymorphisms can partially explain the large inter-individual variation in DNA adduct levels following exposure to polycyclic aromatic hydrocarbons. Effects of genetic polymorphisms on DNA adduct formation are difficult to assess in human studies because exposure misclassification attenuates underlying relationships. Conversely, ex vivo studies offer the advantage of controlled exposure settings,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzo(a)pyrene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogens, Environmental

Share to Catalase

Share to Comet Assay

Share to Cytochrome P-450 CYP1B1

Share to DNA Adducts

Share to NF-E2-Related Factor 2

Source

Identifiers

PMID: 23325794
DOI: 10.1093/mutage/ges070

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo.PMID 23325794Read ↗

Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk.Semantic proximity Read ↗

Human catalase, its polymorphisms, regulation and changes of its activity in different diseases.Semantic proximity Read ↗

Study of promotor -21 A/T polymorphism of catalase CAT (rs7943316) gene in patients with breast cancerSemantic proximity Read ↗

Association between catalase gene polymorphisms and risk of chronic hepatitis B, hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma in Guangxi population: a case-control study.Semantic proximity Read ↗

CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism.Semantic proximity Read ↗

Associations between catalase phenotype and genotype: modification by epidemiologic factors.Semantic proximity Read ↗

Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk.Semantic proximity Read ↗

Benzo[a]pyrene-induced DNA-protein crosslinks in cultured human lymphocytes and the role of the GSTM1 and GSTT1 genotypes.Semantic proximity Read ↗

Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.Semantic proximity Read ↗

CYP1A1, GSTM1, and GSTP1 genetic polymorphisms and urinary 1-hydroxypyrene excretion in non-occupationally exposed individuals.Semantic proximity Read ↗

CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.Semantic proximity Read ↗

Allele-specific induction of IL1B -31T/C promoter polymorphism by lung carcinogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.