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Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2008

Quick Sylvia K, Shields Peter G, Nie Jing, Platek Mary E, McCann Susan E, Hutson Alan D, Trevisan Maurizio, Vito Dominica, Modali Ramakrishna, Lehman Teresa A, Seddon Mike, Edge Stephen B, Marian Catalin, Muti Paola, Freudenheim Jo L

Abstract excerpt

Catalase, a ubiquitous heme enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells from oxidative stress. A C/T polymorphism in the promoter region of the CAT gene (rs1001179) affects transcriptional activity and RBC catalase levels. Oxidative stress may explain the observed increased postmenopausal breast cancer risk associated with hormone replacement therapy (HRT). We...

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Identifiers

PMID: 18483329
DOI: 10.1158/1055-9965.EPI-07-2755

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk.PMID 18483329Read ↗

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