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Article

Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk.

Cancer causes & control : CCC - 1 Dec 2012

McCullough Lauren E, Santella Regina M, Cleveland Rebecca J, Bradshaw Patrick T, Millikan Robert C, North Kari E, Olshan Andrew F, Eng Sybil M, Ambrosone Christine B, Ahn Jiyoung, Steck Susan E, Teitelbaum Susan L, Neugut Alfred I, Gammon Marilie D

Abstract excerpt

PURPOSE: The mechanisms driving the physical activity-breast cancer association are unclear. Exercise both increases reactive oxygen species production, which may transform normal epithelium to a malignant phenotype, and enhances antioxidant capacity, which could protect against subsequent oxidative insult. Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic...

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Identifiers

PMID: 23053794
DOI: 10.1007/s10552-012-0072-1
PMCID: PMC3796339

Genes

CAT
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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