Article
Clinical and psychological outcomes of receiving a variant of uncertain significance from multigene panel testing or genomic sequencing: a systematic review and meta-analysis.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2021
Mighton Chloe, Shickh Salma, Uleryk Elizabeth, Pechlivanoglou Petros, Bombard Yvonne
Abstract excerpt
This study systematically reviewed and synthesized the literature on psychological and clinical outcomes of receiving a variant of uncertain significance (VUS) from multigene panel testing or genomic sequencing. MEDLINE and EMBASE were searched. Two reviewers screened studies and extracted data. Data were synthesized through meta-analysis and meta-aggregation. The search identified 4539 unique studies and 15 were...
Topics
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetic Testing
- Genomics
- Humans