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Variants of Uncertain Clinical Significance as a Result of <i>BRCA1/2</i> Testing: Impact of an Ambiguous Breast Cancer Risk Message

1 Sept 2004

Abstract excerpt

The identification of an increasing number of variants of uncertain clinical significance (VUCS) in genetic testing for hereditary breast cancer poses serious problems for genetic counseling, because no data are available about the psychosocial impact of discussing such an unclear risk message. The current study is the first to present data on how test applicants actually understand and cope with such a result if...

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PMID: 15727245
DOI: 10.1089/gte.2004.8.235

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