Truncation of TRIM5 in the <i>Feliformia</i> Explains the Absence of Retroviral Restriction in Cells of the Domestic Cat

Abstract excerpt

TRIM5alpha mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved across the Feliformia. Cat TRIM5 displayed no restriction activity, but ectopic expression conferred a dominant negative effect against human TRIM5alpha. Our...

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