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Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Tong Lin, Yang Xue-Xi, Liu Min-Feng, Yao Guang-Yu, Dong Jian-Yu, Ye Chang-Sheng, Li Ming

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) is a potential therapeutic target for breast cancer; however, its use does not lead to a marked clinical response. Studies of non-small cell lung cancer and colorectal cancer showed that mutations of genes in the PIK3CA/AKT and RAS/RAF/MEK pathways, two major signalling cascades downstream of EGFR, might predict resistance to EGFR-targeted agents. Therefore,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23317280
DOI: 10.7314/apjcp.2012.13.11.5599

Genes

EGFR
AKT1
BRAF
HRAS
KRAS

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