Article
Paternal Age Explains a Major Portion of De Novo Germline Mutation Rate Variability in Healthy Individuals.
PloS one - 1 Jan 2016
Girard Simon L, Bourassa Cynthia V, Lemieux Perreault Louis-Philippe, Legault Marc-André, Barhdadi Amina, Ambalavanan Amirthagowri, Brendgen Mara, Vitaro Frank, Noreau Anne, Dionne Ginette, Tremblay Richard E, Dion Patrick A, Boivin Michel, Dubé Marie-Pierre, Rouleau Guy A
Abstract excerpt
De novo mutations (DNM) are an important source of rare variants and are increasingly being linked to the development of many diseases. Recently, the paternal age effect has been the focus of a number of studies that attempt to explain the observation that increasing paternal age increases the risk for a number of diseases. Using disease-free familial quartets we show that there is a strong positive correlation...
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