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Article

Off-pathway aggregation can inhibit fibrillation at high protein concentrations.

Biochimica et biophysica acta - 1 Mar 2013

Deva Taru, Lorenzen Nikolai, Vad Brian S, Petersen Steen V, Thørgersen Ida, Enghild Jan J, Kristensen Torsten, Otzen Daniel E

Abstract excerpt

Ribosomal protein S6 fibrillates readily at slightly elevated temperatures and acidic pH. We find that S6 fibrillation is retarded rather than favored when the protein concentration is increased above a threshold concentration of around 3.5mg/mL. We name this threshold concentration C(FR), the concentration at which fibrillation is retarded. Our data are consistent with a model in which this inhibition is due to...

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Identifiers

PMID: 23313095
DOI: 10.1016/j.bbapap.2012.12.020

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