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Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

13 Dec 2021

Abstract excerpt

), is carefully regulated. However, it is unclear whether functional aggregation is inhibited by chaperones targeting pathological misfolding and if so by what mechanism. Here we analyze how four entirely different human chaperones or protein modulators (transthyretin, S100A9, Bri2 BRICHOS and DNAJB6) and bacterial CsgC affect CsgA and FapC fibrillation. CsgA is more susceptible to inhibition than FapC and the...

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PMID: 35126986
DOI: 10.1039/d1sc05790a

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