Article
Ribosomal RNA Modulates Aggregation of the Podospora Prion Protein HET-s.
International journal of molecular sciences - 1 Sept 2020
Pang Yanhong, Kovachev Petar, Sanyal Suparna
Abstract excerpt
The role of the nucleic acids in prion aggregation/disaggregation is becoming more and more evident. Here, using HET-s prion from fungi Podospora anserina (P. anserina) as a model system, we studied the role of RNA, particularly of different domains of the ribosomal RNA (rRNA), in its aggregation process. Our results using Rayleigh light scattering, Thioflavin T (ThT) binding, transmission electron microscopy...
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