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Article

Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease.

Journal of clinical immunology - 1 May 2013

Wada Taizo, Muraoka Masahiro, Toma Tomoko, Imai Tsuyoshi, Shigemura Tomonari, Agematsu Kazunaga, Haraguchi Kohei, Moriuchi Hiroyuki, Oh-Ishi Tsutomu, Kitoh Toshiyuki, Ohara Osamu, Morio Tomohiro, Yachie Akihiro

Abstract excerpt

Chronic granulomatous disease (CGD) is caused by defects of NADPH oxidase. The diagnosis of CGD can be made by analysis of NADPH oxidase activity, however, identification of the CGD subgroups is required before performing mutation analysis. The membrane-bound subunits, gp91phox and p22phox, can be quickly analyzed by flow cytometry, unlike the cytosolic components, p47phox and p67phox. We evaluated the...

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PMID: 23306776
DOI: 10.1007/s10875-012-9859-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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