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Article

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Puckett Susan, Trujillo Carolina, Wang Zhe, Eoh Hyungjin, Ioerger Thomas R, Krieger Inna, Sacchettini James, Schnappinger Dirk, Rhee Kyu Y, Ehrt Sabine

Abstract excerpt

The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilate even-chain fatty acids (FAs) and has been implicated in persistence of Mycobacterium tuberculosis (Mtb). Recent work, however, showed that the first enzyme of the glyoxylate shunt, isocitrate lyase (ICL), may mediate survival of Mtb during the acute and chronic phases of infection in mice through physiologic functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28265055
DOI: 10.1073/pnas.1617655114
PMCID: PMC5358392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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