Article
Caspase-dependent cleavage of the mono-ADP-ribosyltransferase ARTD10 interferes with its pro-apoptotic function.
The FEBS journal - 1 Mar 2013
Herzog Nicolas, Hartkamp Jörg D H, Verheugd Patricia, Treude Fabian, Forst Alexandra H, Feijs Karla L H, Lippok Barbara E, Kremmer Elisabeth, Kleine Henning, Lüscher Bernhard
Abstract excerpt
ADP-ribosylation is a post-translational modification that regulates various physiological processes, including DNA damage repair, gene transcription and signal transduction. Intracellular ADP-ribosyltransferases (ARTDs or PARPs) modify their substrates either by poly- or mono-ADP-ribosylation. Previously we identified ARTD10 (formerly PARP10) as a mono-ADP-ribosyltransferase, and observed that exogenous ARTD10...
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