Article
New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia.
Transfusion - 1 May 2012
Peterson Julie A, Pechauer Shannon M, Gitter Maria L, Kanack Adam, Curtis Brian R, Reese Jeff, Kamath Vasudeva M, McFarland Janice G, Aster Richard H
Abstract excerpt
BACKGROUND: Maternal immunization against low-frequency, platelet (PLT)-specific antigens is being recognized with increasing frequency as a cause of neonatal alloimmune thrombocytopenia (NAIT). STUDY DESIGN AND METHODS: Serologic and molecular studies were performed on PLTs and DNA from two families in which an infant was born with severe thrombocytopenia not attributable to maternal immunization against known...
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