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Article

Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines.

Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2013

Rimchala Tharathorn, Kamm Roger D, Lauffenburger Douglas A

Abstract excerpt

Angiogenesis requires coordinated dynamic regulation of multiple phenotypic behaviors of endothelial cells in response to environmental cues. Multi-scale computational models of angiogenesis can be useful for analyzing effects of cell behaviors on the tissue level outcome, but these models require more intensive experimental studies dedicated to determining the required quantitative "rules" for cell-level...

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Identifiers

PMID: 23303249
DOI: 10.1039/c2ib20090b
PMCID: PMC3581728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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