Article
16(th) IHIW : review of HLA typing by NGS.
International journal of immunogenetics - 1 Feb 2013
De Santis D, Dinauer D, Duke J, Erlich H A, Holcomb C L, Lind C, Mackiewicz K, Monos D, Moudgil A, Norman P, Parham P, Sasson A, Allcock R J N
Abstract excerpt
Human leucocyte antigen (HLA) genes play an important role in the success of organ transplantation and are associated with autoimmune and infectious diseases. Current DNA-based genotyping methods, including Sanger sequence-based typing (SSBT), have identified a high degree of polymorphism. This level of polymorphism makes high-resolution HLA genotyping challenging, resulting in ambiguous typing results due to an...
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