Article
Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.
PloS one - 1 Jan 2013
Hosur Vishnu, Cox Melissa L, Burzenski Lisa M, Riding Rebecca L, Alley Lynn, Lyons Bonnie L, Kavirayani Anoop, Martin Kimberly A, Cox Gregory A, Johnson Kenneth R, Shultz Leonard D
Abstract excerpt
"Hairpatches" (Hpt) is a naturally occurring, autosomal semi-dominant mouse mutation. Hpt/Hpt homozygotes die in utero, while Hpt/+ heterozygotes exhibit progressive renal failure accompanied by patchy alopecia. This mutation is a model for the rare human disorder "glomerulonephritis with sparse hair and telangiectases" (OMIM 137940). Fine mapping localized the Hpt locus to a 6.7 Mb region of Chromosome 4...
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