Article
TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases.
Journal of hematology & oncology - 8 May 2015
Ok Chi Young, Patel Keyur P, Garcia-Manero Guillermo, Routbort Mark J, Peng Jie, Tang Guilin, Goswami Maitrayee, Young Ken H, Singh Rajesh, Medeiros L Jeffrey, Kantarjian Hagop M, Luthra Rajyalakshmi, Wang Sa A
Abstract excerpt
BACKGROUND: TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t-MN versus de novo diseases is largely unknown. METHODS: We collected 108 consecutive patients with therapy-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (t-AML). Clinical, hematological, and cytogenetic data were...
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