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Article

MicroRNA Expression Profiling in HCV-Infected Human Hepatoma Cells Identifies Potential Anti-Viral Targets Induced by Interferon-α

13 Feb 2013

Abstract excerpt

OBJECTIVE: Increasing evidence suggests that miRNAs have a profound impact on host defense to Hepatitis C virus (HCV) infection and clinical outcome of standard HCV therapy. In this study, we investigated modulation of miRNA expression in Huh7.5 hepatoma cells by HCV infection and in vitro interferon-αtreatment. METHODS: MiRNA expression profiling was determined using Human miRNA TaqMan® Arrays followed by...

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PMID: 23418453
DOI: 10.1371/journal.pone.0055733

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