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Article

Cellular microRNA networks regulate host dependency of hepatitis C virus infection

21 Nov 2017

Abstract excerpt

Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mimic and hairpin inhibitor phenotypic screens, and miRNA-mRNA transcriptomics analyses, we identify...

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PMID: 29176620
DOI: 10.1038/s41467-017-01954-x

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