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Article

Zebrafish as a Potential Model Organism for Drug Test Against Hepatitis C Virus

8 Aug 2011

Abstract excerpt

Screening and evaluating anti- hepatitis C virus (HCV) drugs in vivo is difficult worldwide, mainly because of the lack of suitable small animal models. We investigate whether zebrafish could be a model organism for HCV replication. To achieve NS5B-dependent replication an HCV sub-replicon was designed and created with two vectors, one with HCV ns5b and fluorescent rfp genes, and the other containing HCV's 5'UTR,...

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PMID: 21857967
DOI: 10.1371/journal.pone.0022921

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