Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma

Abstract excerpt

BACKGROUND: Treatment options of glioblastoma, the most aggressive primary brain tumor with frequent relapses and high mortality, are still very limited, urgently calling for novel therapeutic targets. Expression of the glycoprotein podoplanin correlates with poor prognosis in various cancer entities, including glioblastoma. Furthermore, podoplanin has been associated with tumor cell migration and proliferation...

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