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Article

Mechanical probes of SOD1 predict systematic trends in metal and dimer affinity of ALS-associated mutants.

Journal of molecular biology - 11 Mar 2013

Das Atanu, Plotkin Steven S

Abstract excerpt

Mutations and oxidative modification in the protein Cu,Zn superoxide dismutase (SOD1) have been implicated in the death of motor neurons in amyotrophic lateral sclerosis (ALS), a presently incurable, invariably fatal neurodegenerative disease. Here we employ steered, all-atom molecular dynamics simulations in implicit solvent to investigate the significance of either mutations or post-translational modifications...

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Source

Identifiers

PMID: 23291526
DOI: 10.1016/j.jmb.2012.12.022

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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