Article
Free energy calculations of ALS-causing SOD1 mutants reveal common perturbations to stability and dynamics along the maturation pathway.
Protein science : a publication of the Protein Society - 1 Sept 2021
Wells Nicholas G M, Tillinghast Grant A, O'Neil Alison L, Smith Colin A
Abstract excerpt
With over 150 heritable mutations identified as disease-causative, superoxide dismutase 1 (SOD1) has been a main target of amyotrophic lateral sclerosis (ALS) research and therapeutic efforts. However, recent evidence has suggested that neither loss of function nor protein aggregation is responsible for promoting neurotoxicity. Furthermore, there is no clear pattern to the nature or the location of these...
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