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Article

Voltage-Induced Misfolding of Zinc-Replete ALS Mutant Superoxide Dismutase-1.

ACS chemical neuroscience - 21 Oct 2015

Shi Yunhua, Acerson Mark J, Shuford Kevin L, Shaw Bryan F

Abstract excerpt

The monomerization of Cu, Zn superoxide dismutase (SOD1) is an early step along pathways of misfolding linked to amyotrophic lateral sclerosis (ALS). Monomerization requires the reversal of two post-translational modifications that are thermodynamically favorable: (i) dissociation of active-site metal ions and (ii) reduction of intramolecular disulfide bonds. This study found, using amide hydrogen/deuterium (H/D)...

Topics

Calorimetry, Differential Scanning
Deuterium Exchange Measurement
Electrophoresis, Capillary
Humans
Models, Chemical
Mutation
Protein Folding
Protein Processing, Post-Translational
Static Electricity
Superoxide Dismutase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Superoxide Dismutase-1

Zinc

Source

Identifiers

PMID: 26207449
DOI: 10.1021/acschemneuro.5b00146

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Voltage-Induced Misfolding of Zinc-Replete ALS Mutant Superoxide Dismutase-1.PMID 26207449Read ↗

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