Article
Discovery of an Experimental Model of Unicuspid Aortic Valve.
Journal of the American Heart Association - 30 Jun 2018
Weiss Robert M, Chu Yi, Brooks Robert M, Lund Donald D, Cheng Justine, Zimmerman Kathy A, Kafa Melissa K, Sistla Phanicharan, Doshi Hardik, Shao Jian Q, El Accaoui Ramzi N, Otto Catherine M, Heistad Donald D
Abstract excerpt
BACKGROUND: The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss-of-function mutation in epithelial growth factor receptor, which are EgfrVel/+ mice, would develop anomalous aortic valves, valve dysfunction, and valvular cardiomyopathy. METHODS AND RESULTS: Aortic valves from EgfrVel/+ mice...
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