Article
VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type.
PloS one - 1 Jan 2012
Nichele Ilaria, Zamò Alberto, Bertolaso Anna, Bifari Francesco, Tinelli Martina, Franchini Marta, Stradoni Roberta, Aprili Fiorenza, Pizzolo Giovanni, Krampera Mauro
Abstract excerpt
BACKGROUND: small B-cell neoplasms can show plasmacytic differentiation and may potentially progress to aggressive lymphoma (DLBCL). Epstein-Barr virus (EBV) infection may cause the transformation of malignant cells in vitro. DESIGN AND METHOD: we established VR09 cell line with plasmacytic differentiation, obtained from a case of atypical, non-CLL B-cell chronic lymphoproliferative disease with plasmacytic...
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